Revolutions of CRISPR/Cas9 in modern era as genome editing tool

Aziz Ullah, Hafiz Ghulam Muhu-Din Ahmed, Syed Wasim Hasan, Abdul Malik

Abstract


CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) is a latest genome engineering technology that has created a buzz in the scientific world as it has enabled scientists and geneticists to efficiently edit genomes of not only prokaryotic but eukaryotic organisms as well including Human beings with a greater level of precision leading to advancements in medical field that possesses genetic components. Technically, CRISPR works by slicing out chunks of DNA & substituting that removed chunk with a new, altered & updated sequence of DNA. This enables the modifications in mutant genes such that the target of curbing the transmission of genetic diseases in descendants could be achieved. CRISPR/Cas9 genome engineering technology is being practiced routinely now a days as it is a faster, cheaper and a more precise technique of DNA editing with a versatile range of potential applications & future perspectives. The readers will get a precise overview of CRISPR/Cas9 genome engineering technology, its mechanism, applications & role in procuring advanced, modified & disease resistant traits in plants & humans with a brief account of ethical considerations after overviewing this review article


Keywords


Genome; Tool; Population; Biotechnology; DNA

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Print ISSN: 2522-6746 ,  Online ISSN: 2522-6754 

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